Nystatin

Oleh .

Bagikan :

Tweet

1.     Brand Name  : Mycostatin [1]
2.     Indication(s)  : Antifungal [2]
3.   Mechanism    : Interaction with ergosterol in the membrane of antibiotic-sensitive organisms, resulting in formation of barrel-like membrane-spanning ion channels [2]. Nystatin also influences cellular function through its interaction with cholesterol to sequester it in the plasma membrane, thereby effectively reducing the ability of cholesterol to interact with and exert its effects on other membrane components [2].
4.  Side Effect(s) : Fever, chills, headache, nausea, vomiting, hypertension/hypotension and hypoxia, and nephrotoxicity [3].
5. Mechanism     : Polyenes induce the production of pro-inflammatory cytokines [3]. Moreover, it is believed that the induction of pro-inflammatory cytokines by polyenes is responsible for many of the acute adverse effects associated with systemic treatment with polyenes [3].
6. Metabolism    : Nystatin is metabolized into 10-deoxynystatin, a nystatin precursor lacking a hydroxyl group at C-10 [4].

REFERENCES :

1.      http://www.ncbi.nlm.nih.gov/pubmed/9529849  -  Ali S.A., et., J Pak Med Assoc. 1997 Oct;47(10):246-8.

2.      http://www.ncbi.nlm.nih.gov/pubmed/24009857 - Baek S., et al., Biomol Ther (Seoul). 2013 January; 21(1): 42–48.

3.      http://www.ncbi.nlm.nih.gov/pubmed/10696790  - Larson J.L., et al., Toxicol Sci.2000 Feb;53(2):421-9.

4.      http://www.ncbi.nlm.nih.gov/pubmed/16251298 - Sletta H., et al., Antimicrob Agents Chemother. 2005 November; 49(11): 4576–4583.

Tag : Farmasi